![]() ![]() This pathological condition causes significant pain and disability and negatively impacts the well-being of both humans and dogs 1, 2, 3. Osteoarthritis (OA) is a widely recognized chronic illness that affects the entire joint. These results prove that 1H-NMR-based metabolomic analysis is a valid tool to study and monitor OA and that UC-II improves clinical symptoms and the SF metabolic profile in OA dogs. The unexpectedly high level of lactate in the OA-free group suggests that lactate could not be considered a good marker for OA. The absence of β-hydroxybutyrate after UC-II supplementation suggests the supplement’s effectiveness in rebalancing the metabolism inside the joint. β-Hydroxybutyrate was identified as a characteristic compound of osteoarthritic joints, showing the important role of fat metabolism during OA. The multivariate statistical analysis performed on SFs under different conditions (OA-T0 vs OA-T30 SFs OA-T0 vs OA-free SFs and OA-T30 vs OA-free SFs) gave models with excellent goodness of fit and predictive parameters, revealed by a marked separation between groups. The differences in the 1H-NMR metabolic SFs profiles between groups (OA-free, OA-T0 and OA-T30) were studied. After this period, they were reassessed (OA-T30). All dogs included in OA group were supplemented with UC-II orally administered for 30 days. All dogs were clinically evaluated and underwent SF sampling for 1H-Nuclear Magnetic Resonance spectroscopy ( 1H-NMR) analysis at time of presentation. Client-owned dogs were enrolled in the study and randomized in two different groups, based on the presence/absence of OA (OA group and OA-free group). The aim of the study was to compare the metabolomic synovial fluid (SF) profile of dogs affected by spontaneous osteoarthritis (OA) and supplemented with undenatured type II collagen (UC-II), with that of healthy control dogs. ![]()
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